Design of an Integrative Algorithm for Staging Tuberculosis

• Changes in Biomarkers values[ Time Frame: timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) ]
  Changes in the biomarkers along time assessed by using analyzing parameters in blood and urine samples (by ELISA and LUMINEX)
• Radiological Score Value[ Time Frame: timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) ]
  Changes in the BCN-SA Radiological Score Value. This Score assesses the sum of acute and chronic findings in the chest X-ray. Per each finding, a maximum score of 8 is recorded. The total score value is calculated by adding all the individual findings score values. Higher values of total score represent a worse outcome.
• Changes in SGRQ score[ Time Frame: timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) ]
  Changes in Health Quality of Life measures along time assessed by using the Saint George's Respiratory Questionnaire (SGRQ, numeric score). It measures 3 subscales (symptoms/activity/impacts) and The Total score is calculated by summing all positive responses in the questionnaire and expressing the result as a percentage of the total weight for the questionnaire. Higher values represent a worse outcome.
• Changes in Kessler-10 score[ Time Frame: timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) ]
  Changes in Health Quality of Life measures along time assessed by using the questionnaire Kessler-10 (K10, numeric score). Higher values represent a worse outcome.
• Changes in Health Quality of Life measures along time using BCN-Q questionnaire[ Time Frame: timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) ]
  Changes in Health Quality of Life measures along time using BCN-Q questionnaire (descriptive questionnaire).
• Anthropological description[ Time Frame: months 0 to 6 ]
  Anthropological description of TB patients included in the cohort

Tuberculosis is a chronic infectious disease that affects 10 million people, 300 in the city of Barcelona, every year. With serious consequences at public health level, it is associated with other diseases, and generated and influenced by many social and psychological factors. This study aims to stage tuberculosis disease by an integrative approach.

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• : TB patients
  TB patients diagnosed and followed-up in Barcelona, at the following Hospitals/Clinics: Servicios Clínicos, Hospital Universitari Germans Trias i Pujol, Hospital Universitari Vall d'Hebron-Drassanes.