Homoarginine Supplementation in Patients After Stroke

• Intima-media thickness[ Time Frame: six month ]
  Intima-media thickness (IMT) measured at both common carotid arteries using an edge detection system. Plaques are defined as protrusion of ≥1.5 mm in common, internal and external carotid artery.
• National Institute of Health Stroke Scale[ Time Frame: six month ]
  National Institute of Health Stroke Scale (NIHSS) will be assessed by a neurologist. The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 (normal) and 4 (maximum impairment). The maximum possible score is 42, with the minimum score being a 0.
• Modified Ranking Scale[ Time Frame: six month ]
  Modified Ranking Scale (mRS) is a scale for measuring the degree of disability of a stroke patients. The scale runs from 0 (perfect health) to 6 (death).

This study represents a follow-up of the previous study "Single and Multiple Doses of an Oral Formulation of L-Homoarginine in Healthy Human Subjects" (NCT02675660). This study will evaluate the applicability of an oral formulation of L-homoarginine to normalize homoarginine blood levels in patients with acute ischemic stroke.

• Dietary Supplement: 125 mg L-homoarginine
  capsules for oral supplementation
• Other: placebo
  capsules for oral supplementation

• Placebo Comparator: placebo
  placebo capsules containing lactose - oral once daily for three days followed by six month once weekly administration
• Active Comparator: homoarginine
  125 mg L-homoarginine supplement - oral once daily for three days followed by six month once weekly administration