Evolution of Lung 18FDG Uptake in Patients With Idiopathic Pulmonary Fibrosis and Receiving Pirfenidone

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追踪信息

首次提交日期 ^ICMJE

September 14, 2018

首次发布日期e ^ICMJE

October 2, 2018

最后更新发布日期

October 2, 2018

预计研究开始日期 ^ICMJE

November 30, 2018

预计主要完成日期

November 30, 2020 (主要结果测量的最终数据收集日期)

目前主要观察指标 ^ICMJE

Changes of 18FDG lung uptake (TLG variation) in patients with IPF 12 weeks after the initiation of pirfenidone[ Time Frame: 12 weeks ]

To describe the changes of 18FDG lung uptake assessed by TLG variation in patients with IPF 12 weeks after the initiation of pirfenidone

原始主要观察测量 ^ICMJE

与当前相同

目前的二级观察 ^ICMJE

Change of 18FDG lung uptake in patients with IPF 12 weeks after the initiation of pirfenidone : variation of SUVmean between baseline and after 12 weeks of treatment[ Time Frame: 12 weeks ]
Values of SUVmean will be compared between baseline (treatment initiation with pirfenidone) and the 12 weeks using a Wilcoxon's signed rank test
Change of 18FDG lung uptake in patients with IPF 12 weeks after the initiation of pirfenidone : variation of SUVmax between baseline and after 12 weeks of treatment[ Time Frame: 12 weeks ]
Values of SUVmax will be compared between baseline (treatment initiation with pirfenidone) and the 12 weeks using a Wilcoxon's signed rank test
Change of 18FDG lung uptake in patients with IPF 12 weeks after the initiation of pirfenidone : variation of MLV between baseline and after 12 weeks of treatment[ Time Frame: 12 weeks ]
Values of MLV will be compared between baseline (treatment initiation with pirfenidone) and the 12 weeks using a Wilcoxon's signed rank test
Variation of PET parameters (SUVmean, SUVmax, TLG and MLV values) between baseline and 12 weeks and FVC at 12, 24, 36 and 48 weeks[ Time Frame: 48 weeks ]
Relationship between the variation of each PET parameter between baseline and 12 weeks after treatment initiation and the decline of FVC over time will be assessed using a linear mixed effect model of the evolution of FVC over time and the effect of the change of each PET parameter on the decline of FVC over time will be tested
Evaluation of the performance of the PET scanner (Sensitivity, Specificity, Positive predictive value and Negative predictive value) using the variation of each PET parameter and the therapeutic response at 24 weeks (succes versus failure)[ Time Frame: 24 weeks ]
The performance of the PET scanner (Sensitivity, Specificity, Positive predictive value, and Negative predictive value) will be studied using the variation of each PET parameter and the therapeutic response at 24 weeks. A non-parametric Wilcoxon test will be used to compare the variation of each PET parameter according to the therapeutic response. The therapeutic response will be classified as therapeutic failure in the case of any of the following events between pirfenidone treatment initiation and 24 weeks: a relative decline in percent predicted FVC ≥10%, an absolute decline in 6MWT distance ≥50 m, or death from any cause, or as therapeutic success (in any other case).

描述性信息

简略标题 ^ICMJE

Evolution of Lung 18FDG Uptake in Patients With Idiopathic Pulmonary Fibrosis and Receiving Pirfenidone

正式标题 ^ICMJE

Evolution of Lung 18FDG Uptake in Patients With Idiopathic Pulmonary Fibrosis and Receiving Pirfenidone

简要概况

Idiopathic pulmonary fibrosis (IPF) is a rare and fatal lung disease characterized by unpredictable changes with variable kinetics of progression. Changes in pulmonary function (FVC, DLCO) assessed at the time of diagnosis, or decline in pulmonary function within 12 months after diagnosis, are the best predictors of survival, but poorly predicted disease activity and evolution. 18FDG positron emission tomography (18FDG PETscan) provides the ability to quantify cell metabolism in vivo and non-invasively using a labeled non-metabolizable substrate. Several parameters can be measured in an automated and reproducible way, such as the mean fixation intensity (SUV mean), the maximum fixation intensity (SUV max), the hyperfixing volume measurement (MLV) or the glycolytic activity measurement tissue or TLG (total lesions glycolysis). Several studies have demonstrated an increase of glycolytic activity in lung fibroblast from IPF patient. In a recent study, our team demonstrated a strong correlation between the lung uptake parameters and the lung function tests results (LFTs) and prognostic score GAP. In addition, MLV and TLG were factors prognostic and independently associated with progression-free survival at 12 months. In a preliminary study, the investigators studied the change of these parameters in twelve patients treated with pirfenidone for IPF who performed an 18FDG PETscan before the initiation of treatment and about twelve weeks later. A mean decrease of 30% in TLG value between the two evaluations was observed. These preliminary data suggest that pirfenidone influences lung metabolism in patients with IPF. The investigators aim to conduct a prospective study to confirm and refine the preliminary data.

详细说明

Idiopathic pulmonary fibrosis (IPF) is a rare and fatal lung disease characterized by an unpredictable evolution with variable kinetics of progression and burdened by the occurrence of exacerbation. The evaluation of the prognosis in a given patient remains difficult. Impaired lung function assessed by the value of forced vital capacity (FVC) and diffusion of lung carbon monoxide (DLCO) at the time of diagnosis, or decline in lung function within 6 or 12 months after the diagnosis, are the best predictive markers of survival but fail to assess or to predict lung function decline. Until recently, lung transplantation was the only IPF treatment and remains associated with high morbidity and mortality. Pirfenidone and nintedanib - anti-fibrotic treatments - are now validated therapies in the management of mild-to-moderate IPF defined by FVC ≥ 50% of predictive value and by DLCO ≥ 30 % of predicted value. Several international clinical trials demonstrated that pirfenidone and nintedanib significantly reduce the lung function decline and the exacerbations incidence and significantly improve survival. The emergence of these innovative but costly therapies - which are associated with a non-negligible rate of adverse effects - requires the development of tools to evaluate their effectiveness and monitor anti-fibrotic activity. The 18-fluorodesoxyglucose (18FDG) lung uptake may be the first tool to predict early therapeutic response. PET offers the possibility to quantify in vivo and non-invasively the cell metabolism, using a non-metabolizable substrate labeled as 18FDG. Several parameters can be measured in an automated and reproducible manner such as the mean uptake intensity (SUV mean), the maximum uptake intensity (SUV max), the metabolic lung volume measurement (MLV) or finally the measurement of tissue glycolytic activity or TLG (total lesion glycolysis). 18FDG PET scanner plays a key role in the diagnosis and monitoring of neoplasia and inflammatory diseases such as sarcoidosis. Recent studies reported a change of the metabolic activity of pulmonary fibroblasts issued from IPF, showing increase of glycolytic activity. In a recent study, our team demonstrated a strong correlation between the lung uptake parameters and the lung function tests results and prognostic score GAP. In addition, MLV and TLG were prognostic and independently associated with progression-free survival at 12 months. Preliminary data suggest that the intensity of lung 18FDG uptake may be a prognostic marker but also a predictive marker of response to anti-fibrotic treatments. A prospective study must be conducted to confirm or refute these observations. Primary objective: The main objective of this study is to describe the changes of 18FDG lung uptake assessed by TLG variation in patients with IPF, 12 weeks after the initiation of pirfenidone. Secondary objectives: Secondary objectives include the following : 1. To describe the changes of 18FDG lung uptake assessed by other 18FDG indices (SUVmean, SUVmax and MLV) in patients with IPF, 12 weeks after the initiation of pirfenidone ; 2. To study the relationship between the variation of 18FDG lung uptake 12 weeks after the initiation of pirfenidone therapy (as assessed by the changes of TLG, SUVmean, SUVmax and MLV) and the decline of FVC 12, 24, 36 and 48 weeks after the initiation of pirfenidone therapy ; 3. To estimate the predictive performance of the variation of 18FDG lung uptake 12 weeks after the beginning of pirfenidone therapy for therapeutic efficacy at 24 weeks. Experimental plan: This is an interventional, prospective, multicenter, proof of concept study. 18FDG PET-scanner will be performed at baseline and 12 weeks after the beginning of pirfenidone treatment in each patient. Lung Function Tests will be also performed before and 12 weeks after initiation of pirfenidone treatment and will be repeated every 12 weeks until 48 weeks after pirfenidone initiation. A clinical examination and liver enzymes will be assessed every 12 weeks. The occurrence of any adverse event will be collected throughout the trial. LFTs will be interpreted blindly from the results of 18FDG uptake.

研究类型 ^ICMJE

Interventional

研究阶段

N/A

研究设计 ^ICMJE

分配:
干预模型: Single Group Assignment
干预模型描述:
盲法: Interventional
盲法描述:
主要目的: Other

适用条件 ^ICMJE

干预项目 ^ICMJE

Radiation: 18FDG-PET scan
18FDG PET scan will be performed in each patient before initiation of pirfenidone and after 12 weeks of treatment

研究工具

Experimental: 18FDG-PET scan
18FDG PET scan will be performed in each patient before initiation of pirfenidone and after 12 weeks of treatment

招募信息

招募状态 ^ICMJE

Not yet recruiting

预计入组 ^ICMJE

原始预计入组 ^ICMJE

与当前相同

预计研究完成日期

March 31, 2021

预计主要完成日期

November 30, 2020 (主要结果测量的最终数据收集日期)

合格标准 ^ICMJE

Inclusion Criteria: 1. IPF, diagnosed accordingly to ATS/ERS/JRS/ALAT international guidelines 2. FVC≥50% and DLCO≥30% 3. Decision to initiate a treatment with pirfenidone 4. Affiliation to the French social security system Exclusion Criteria: Will be non-eligible in this study any patient: 1. with an age lower than 18 years 2. with a life expectancy lower than 12 months as assessed by the investigator 3. taking an anti-fibrotic treatment (pirfenidone, nintedanib or any experimental molecule) in the previous three months 4. treated by corticosteroid therapy (daily dose > 10 mg, prednisone equivalent) 5. with neoplasia localized in thorax 6. with contraindication to pirfenidone according to the French Summary of Product Characteristics : hypersensitivity to the active substance or to any of the excipients, past history of angioedema with pirfenidone, concomitant treatment with fluvoxamine, severe or terminal hepatic insufficiency, severe renal insufficiency (CrCl <30ml / min) or end-stage requiring dialysis 7. with a positive pregnancy test or currently breastfeeding 8. with contraindication to performing a 18FDG PETscan, ie 18FDG hypersensitivity 9. with emphysema extension >15% on HRCT according to Cottin et al (16).

性别

参与研究的性别:

All

年龄

最小年龄：18 Years ，最大年龄：N/A

接受健康的志愿者

没有

可入组国家 ^ICMJE

France

管理信息

数据检测委员会

研究涉及美国FDA监管的产品

研究美国FDA监管的药品: No
研究涉及美国FDA监管的设备产品: No

IPD 共享声明

计划分享 IPD:

Undecided

责任方

，

研究赞助商 ^ICMJE

Assistance Publique - Hôpitaux de Paris

合作者 ^ICMJE

研究员 ^ICMJE

Principal Investigator: Bruno Crestani, MD, PhD Assistance Publique - Hôpitaux de Paris

PRS 账户

验证日期

September 2018

^ICMJE 国际医学期刊编辑委员会和世界卫生组织 ICTRP 要求的元素

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