Clinical and Live Birth Rates After Following Long Antagonist Protocol Versus Long Agonist Protocol

赞助:

合作者:

信息的提供 (责任方):

Papanikolaou Evaggelos，Assisting Nature

追踪信息

首次提交日期 ^ICMJE

September 24, 2018

首次发布日期e ^ICMJE

October 3, 2018

最后更新发布日期

October 3, 2018

预计研究开始日期 ^ICMJE

January 12, 2017

预计主要完成日期

August 31, 2019 (主要结果测量的最终数据收集日期)

目前主要观察指标 ^ICMJE

Clinical Pregnancy Rate according to stimulation protocol[ Time Frame: 6 weeks to 42 weeks after embryo transfer ]

Clinical Pregnancy Rate according to stimulation protocol

Number of formed blastocysts in each group of patients[ Time Frame: 5 days after the OPU day ]

The number of the formed blastocysts in each group of patients according to the COS protocol

原始主要观察测量 ^ICMJE

与当前相同

目前的二级观察 ^ICMJE

Live Birth Rate according to stimulation protocol[ Time Frame: 6 weeks to 42 weeks after embryo transfer ]
Live Birth Rate according to stimulation protocol

描述性信息

简略标题 ^ICMJE

Clinical and Live Birth Rates After Following Long Antagonist Protocol Versus Long Agonist Protocol

正式标题 ^ICMJE

Clinical and Live Birth Rates After Controlled Ovarian Stimulation With the Long Antagonist Protocol Versus the Long Agonist Protocol

简要概况

A prospective study of the evaluation of the clinical IVF (in vitro fertilization) results after following Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus following Long Agonist protocol

详细说明

A prospective study of the clinical results in women who followed the Long Antagonist protocol for Controlled Ovarian Stimulation (COS) versus women who followed Long Agonist protocol, in an In Vitro Fertilization (IVF) try. In particular, the Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR) were estimated for the two groups of patients. The number of the formed blastocysts was also measured in each group of patients.

研究类型 ^ICMJE

Observational

研究阶段

研究设计 ^ICMJE

分配:
干预模型:
干预模型描述:
盲法: Observational
盲法描述:
主要目的:

适用条件 ^ICMJE

干预项目 ^ICMJE

Diagnostic Test: Clinical Pregnancy Rate
The Clinical Pregnancy, Live Birth Rate and Blastulation Rate according to the protocol of COS

研究工具

: Long Antagonist Protocol
Clinical Pregnancy Rate, Live Birth Rate and Blastulation Rate of patients who followed Long Antagonist Protocol for Controlled Ovarian Stimulation.
: Long Agonist Protocol
Clinical Pregnancy Rate and Live Birth Rates and Blastulation Rate of patients who followed Long Agonist Protocol for Controlled Ovarian Stimulation.

招募信息

招募状态 ^ICMJE

Recruiting

预计入组 ^ICMJE

120

原始预计入组 ^ICMJE

与当前相同

预计研究完成日期

August 31, 2019

预计主要完成日期

August 31, 2019 (主要结果测量的最终数据收集日期)

合格标准 ^ICMJE

Inclusion Criteria: - primary infertility - age 18-39 years; body mass index (BMI) 18-29kg/m2; - regular menstrual cycle of 26-35days, - presumed to be ovulatory; - early follicular- phase serum concentration of FSH within normal limits (1-12 IU/l). Exclusion Criteria: - women with diabetes and other metabolic disease - women with heart disease, QT prolongation,heart failure - elevated liver enzymes, liver failure, hepatitis - women with inflammatory or autoimmune disease - abnormal karyotype; - polycystic ovarian syndrome, - endometriosis stage III/IV; - history of being a 'poor responder', - defined as >20 days of gonadotrophin in a previous stimulation cycle, or any previous cancellation of a stimulation cycle due to limited follicular response, or development of less than 4 follicles 15 mm in a previous stimulation cycle; history of recurrent miscarriage; severe OHSS in a previous stimula- tion cycle or any contraindication for the use of gonadotrophins.

性别

参与研究的性别:

Female

年龄

最小年龄：18 Years ，最大年龄：39 Years

接受健康的志愿者

没有

可入组国家 ^ICMJE

Greece

管理信息

数据检测委员会

Yes

研究涉及美国FDA监管的产品

研究美国FDA监管的药品: No
研究涉及美国FDA监管的设备产品: No

IPD 共享声明

计划分享 IPD:

Undecided

责任方

Papanikolaou Evaggelos，Assisting Nature

研究赞助商 ^ICMJE

Assisting Nature

合作者 ^ICMJE

研究员 ^ICMJE

Principal Investigator: Robert Najdecki, MD, PhD Assisting Nature

PRS 账户

Assisting Nature

验证日期

October 2018

^ICMJE 国际医学期刊编辑委员会和世界卫生组织 ICTRP 要求的元素

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