Investigating Musculoskeletal Health and Wellbeing

• 1. Classification of phenotypic subgroups[ Time Frame: 5 years ]
  Demographic characteristics will be recorded; age at baseline, sex, race, socioeconomic position (deprivation index, urban/rural indicators will be derived from postcode data), smoking habits, weight, height and alcohol consumption. Fracture risk will be assessed using a modified version of the FRAX instrument (substituting secondary osteoporosis for self-reported osteoporosis and without using data for bone mineral density measurements).
• 2. Classification of comorbid conditions[ Time Frame: 5 years ]
  Co-morbidities will be assessed using the Charlson Comorbidity Index
• 3. Medication usage[ Time Frame: 5 years ]
  Participants will self-report their current medications (prescribed and over the counter).
• 4. Identification of potential research participants[ Time Frame: 5 years ]
  The Charlson Comorbidity Index
• Prevalence of Comorbid conditions[ Time Frame: 5 years ]
  the count of comorbidities
• Classification of Rheumatic Comorbid conditions[ Time Frame: 5 years ]
  Rheumatic Disease Comorbidity Index (RDCI).

Background The progression and associations of central and peripheral musculoskeletal pain, frailty, disability and fracture risks are not well known. This study aims to characterise the development and progression of different frailty, pain and disability phenotypes and their individual associations. Methods A prospective cohort of 10000 people aged > 18 will be recruited from general practice surgeries, secondary care and the general public. Data collection waves will be at baseline,and then annual follow-ups for up to five years. Data will be collected using a questionnaire asking about demographic characteristics, pain severity (0-10 scales), pain distribution (a pain Mannikin), pain quality (the McGill Pain Questionnaire), central pain (the CAP-Knee Scale), fracture risks (a modified version of the FRAX instrument), frailty (the Fried Criteria and the FRAIL scale) and disability (the FRAIL scale). Discussion Participant data will be analysed to determine phenotypic subgroups of frailty, pain and disability. Further to this, the progression of these characteristics and their influences upon health and wellbeing will be quantified.

• Other: questionnaire
  questionnaire

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