A Study of an Accelerated Infusion Rate of Daratumumab in Patients With Relapsed and Refractory Multiple Myeloma
赞助:
Myeloma Canada Research Network
合作者:
信息的提供 (责任方):
，
| 追踪信息 | |||
|---|---|---|---|
| 首次提交日期 ICMJE | October 2, 2018 | ||
| 首次发布日期e ICMJE | October 5, 2018 | ||
| 最后更新发布日期 | October 5, 2018 | ||
| 预计研究开始日期 ICMJE | November 2018 | ||
| 预计主要完成日期 | February 2020 (主要结果测量的最终数据收集日期) | ||
| 目前主要观察指标 ICMJE |
Incidence of infusion related reactions (IRRs)[ Time Frame: First 6 months of daratumumab administration ] For an accelerated infusion schedule compared to the approved schedule |
||
| 原始主要观察测量 ICMJE | 与当前相同 | ||
| 目前的二级观察 ICMJE |
|
||
| 描述性信息 | |||
| 简略标题 ICMJE | A Study of an Accelerated Infusion Rate of Daratumumab in Patients With Relapsed and Refractory Multiple Myeloma | ||
| 正式标题 ICMJE | A Phase 2 Open Label Study of an Accelerated Infusion Rate of Daratumumab in Patients With Relapsed and Refractory Multiple Myeloma | ||
| 简要概况 | Primary objective: To determine the incidence of infusion related reactions (IRR's) in the first 6 months of daratumumab administration. |
||
| 详细说明 | Study Design: This is an open label phase II study of a daratumumab accelerated infusion regimen and a fixed pre- and post-medication regimen, in patients with relapsed and refractory Multiple Myeloma. Patients will receive daratumumab, in the following schedule: Daratumumab 8mg/kg in 500 mL over 4 hours Cycle 1 Day 1, Daratumumab 16mg/kg in 500 mL over 90 minutes (20% of dose given in first 30 minutes and remaining 80% of dose given over 60 minutes) Cycle 1 Days 8, 15 and 22; Cycle 2 Days 1, 8, 15, and 22 and on Days 1 and 15 for Cycles 3-6, and Day 1 of each cycle for Cycle 7 and beyond for each 28-day cycle. The study will begin with a 6-patient lead-in phase where safety with regards to the number of Grade 4 infusion related reactions with the accelerated infusion protocol will be evaluated in real time. Accrual to the study will not stop during this evaluation. The safety information obtained will be reviewed and evaluated in the context of previously published data. The review will be conducted by a 3-physician panel and if serious safety concerns (defined as Grade 4 infusion related reactions and/or death) are identified, the panel will make recommendations about protocol modifications if deemed necessary. Pre- and post-medication regimen: Montelukast 10 mg po x 2 days prior to daratumumab administration and 10 mg po the morning of daratumumab administration. Cetirizine 10 mg po x 2 days prior to daratumumab administration and 10 mg po the morning of daratumumab administration. Dexamethasone 20mg on days of and day following daratumumab administration. Acetaminophen 1g po 1 hour prior to daratumumab administration. Diphenhyramine 50mg IV 1 hour prior to daratumumab infusion. Individual subjects will remain on treatment as long as there is no evidence of disease progression or unacceptable toxicity or until a patient/physician decision to discontinue is made. Disease assessments as determined by the Site Investigator will be made according to the IMWG response criteria guidelines for MM.1 As this study is designed to evaluate the IRRs associated with a shortened infusion time of daratumumab administration over a 6-month time period, subjects will be followed on study for a maximum of 6 months following enrollment. Following this time period, all subjects who continue to have a response to daratumumab will be taken off study. Although the study may end before subjects progress from their disease, daratumumab treatment will continue until disease progression in the absence of uncontrolled side effects or voluntary discontinuation of treatment for any reason, although drug will be supplied outside of the clinical trial setting. | ||
| 研究类型 ICMJE | Interventional | ||
| 研究阶段 | Phase 2 | ||
| 研究设计 ICMJE | 分配: 干预模型: Single Group Assignment 干预模型描述: 盲法: Interventional 盲法描述: 主要目的: Treatment |
||
| 适用条件 ICMJE | |||
| 干预项目 ICMJE |
|
||
| 研究工具 |
|
||
| 招募信息 | |||
| 招募状态 ICMJE | Not yet recruiting | ||
| 预计入组 ICMJE |
40 | ||
| 原始预计入组 ICMJE | 与当前相同 | ||
| 预计研究完成日期 | February 2020 | ||
| 预计主要完成日期 | February 2020 (主要结果测量的最终数据收集日期) | ||
| 合格标准 ICMJE | Inclusion Criteria: 1. Males or females, age 18 years or older. 2. ECOG performance status score of 0, 1 or 2. 3. Life expectancy of at least 3 months 4. Measurable disease according to the IMWG criteria defined below (These baseline laboratory studies for determining eligibility must be obtained during the screening period within 28 days prior to start of study drug): 1. Serum monoclonal paraprotein (M-protein) ≥ 10 g/L (if IgG) or ≥5g/L (if IgA, D, E or M). 2. Urine M-protein ≥ 200 mg/24 h. 3. Serum free light chains (FLC) assay: Involved FLC level ≥ 100 mg/L and an abnormal serum free light chain ratio (< 0.26 or > 1.65) 5. Received at least 3 prior lines of therapy including a proteasome inhibitor (≥2 cycles or 2 months of treatment) and an IMiD (≥2 cycles or 2 months of treatment) in any order or in combination during the course of treatment or subjects whose disease is double refractory to a PI and an IMiD. For subjects who have received more than 1 type of PI, their disease must be refractory to the most recent one. Similarly, for those who have received more than 1 type of IMID, their disease must be refractory to the most recent one. **A single line of therapy may consist of 1 or more agents, and may include induction, hematopoietic stem cell transplantation, and maintenance therapy (refer to Appendix 2). Radiotherapy, bisphosphonate, or a single short course of steroids (i.e. less than or equal to the equivalent of dexamethasone 40 mg/day for 4 days) would not be considered prior lines of therapy. Have achieved at least a minimal response (MR) or better to at least one previous line of therapy as per EBMT response criteria. 6. The following laboratory results must be met within 10 days of first study drug administration: 1. ANC ≥ 1.0 x 109/L 2. Hemoglobin ≥ 80 g/L 3. Platelets ≥ 70 x 109/L (or ≥50 x 109/L if ≥ 50% plasmacytosis in bone marrow) 4. Calculated or measured CrCl ≥ 30 mL/min 5. AST and ALT ≤ 3.0 x ULN 6. Total bilirubin ≤ 2 x ULN unless known to have Gilbert's disease 7. Corrected serum calcium ≤ 3.5 mmol/L 7. Have signed the informed consent documents indicating that the subject understands the purpose of the procedures required for the study and is willing to participate and adhere to the study protocol. 8. Females with child-bearing potential (FCBP†) must agree to use 2 reliable forms of contraception* simultaneously or practice complete abstinence from heterosexual contact for at least 28 days before starting study drug, while participating in the study (including during dose interruptions), and for at least 3 months after study treatment discontinuation. †Females of childbearing potential (FCBP): a female of childbearing potential is a sexually mature woman who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months). * The two methods of birth control used may be selected from the following categories, but the two methods cannot be selected from any one category: barrier method: i.e., condom (male or female) or diaphragm with spermicide; hormonal: i.e., contraceptive pill, patch; intrauterine device (IUD); vasectomy; or tubal ligation. 9. Females must agree to abstain from breastfeeding during study participation and 90 days after study drug discontinuation. 10. Males must agree to use a latex condom during any sexual contact with FCBP while participating in the study and for 3 months following discontinuation from this study, even if he has undergone a successful vasectomy. 11. Males must also agree to refrain from donating semen or sperm during the treatment phase and for 3 months after discontinuation from this study treatment. 12. All subjects must agree to refrain from donating blood while on study therapy and for 28 days after discontinuation from this study treatment. Exclusion Criteria: 1. Prior exposure to daratumumab (or other anti-CD38 monoclonal antibody). 2. History of prior allogeneic stem cell transplantation and showing evidence of active graft-versus-host disease or graft-versus-host disease that requires immunosuppressive therapy. 3. Chemotherapy or other anti-myeloma therapy within 14 days prior to the first dose of study drug. 4. Treatment-related toxicity that has not recovered ≤Grade 1 unless deemed to be irreversible (an example of an irreversible toxicity would include steroid induced cataracts). 5. Subjects who have received steroids within 2 weeks prior to starting study treatment or who have not recovered from side effects of such therapy. Concomitant therapy medications that include corticosteroids are allowed if subject receive ≤ 10 mg of prednisone per day, or equivalent, as indicated for other medical conditions, or up to 100 mg of hydrocortisone as pre-medication for administration of certain medications or blood products prior to enrolment in this study. 6. Subjects who have received any investigational agents within 28 days or 5 half-lives (whichever is shorter, however the minimum allowed timeframe is 14 days) of the first dose (Cycle 1 Day 1). 7. Prior history of malignancies, other than MM, unless the subject has been free of the disease for 3 years or longer. Exceptions include the following: 1. Basal or squamous cell carcinoma of the skin 2. Carcinoma in situ of the cervix or breast 3. Adenocarcinoma of the prostate (TNM stage of T1a or T1b) 8. Other concurrent severe and/or uncontrolled medical conditions (i.e. uncontrolled diabetes, active or uncontrolled infection, acute diffuse pulmonary disease, pericardial disease, uncontrolled thyroid dysfunction) including abnormal laboratory values, that could cause unacceptable safety risks or compromise compliance with the protocol. 9. Known chronic obstructive pulmonary disease (COPD), defined as a FEV1 < 50% predicted value. 10. Known moderate or severe persistent asthma within the last 2 years, or currently has uncontrolled asthma of any classification. 11. History of or current uncontrolled cardiovascular disease including: 1. Unstable angina, myocardial infarction, or known congestive heart failure Class III/IV (Appendix 4) within the preceding 12 months 2. Transient ischemic attack within the preceding 3 months, pulmonary embolism within the preceding 2 months. 3. Any of the following: sustained ventricular tachycardia, ventricular fibrillation, Torsades de Pointes, cardiac arrest, Mobitz II second degree heart block or third-degree heart block; known presence of dilated, hypertrophic, or restrictive cardiomyopathy. 4. QTc prolongation as confirmed by ECG assessment at screening (QTc >470 milliseconds). 12. Women who are pregnant, breastfeeding or planning to become pregnant while enrolled in this study, or within 6 months after the last dose of study medications. Male subject who plans to father a child while enrolled in this study, within 90 days after the last dose of study medications. 13. Known HIV positivity or active infectious hepatitis B or C. 14. Known allergies, hypersensitivity to mannitol, corticosteroids, monoclonal antibodies or human proteins, or their excipients (refer to the Daratumumab IB), or known sensitivity to mammalian-derived products. 15. Known CNS involvement, amyloidosis, or currently active plasma cell leukemia. 16. Subjects who are receiving any other investigational agent. 17. Autologous, peripheral stem cell transplant within 12 weeks of the first dose of study drug. 18. Any other condition that, in the Investigator's opinion, would contraindicate the patient's participation in the clinical study due to safety concerns or compliance with clinical study procedures. | ||
| 性别 |
|
||
| 年龄 | 最小年龄：18 Years ，最大年龄：N/A | ||
| 接受健康的志愿者 | 没有 | ||
| 可入组国家 ICMJE | |||
| 管理信息 | 数据检测委员会 | Yes | |
| 研究涉及美国FDA监管的产品 |
研究美国FDA监管的药品: No 研究涉及美国FDA监管的设备产品: No |
||
| IPD 共享声明 |
|
||
| 责任方 | ， | ||
| 研究赞助商 ICMJE | Myeloma Canada Research Network | ||
| 合作者 ICMJE | |||
| 研究员 ICMJE |
|
||
| PRS 账户 | |||
| 验证日期 | August 2018 | ||
|
ICMJE 国际医学期刊编辑委员会和 世界卫生组织 ICTRP 要求的元素 |
|||
请使用微信扫码报名
京公网安备 11010102003638号