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这是一项关于1型神经纤维瘤病的I 期 / II 期研究，登记的药物或干预包括AZD6244，当前状态为研究进行中，已停止招募。登记地点显示中国Washington D.C.、Bethesda、Cincinnati、Philadelphia有研究中心记录。是否仍有名额以及是否值得进一步询问，需要向研究中心确认。
药物或干预
AZD6244 · I 期 / II 期
登记条件中文摘要
登记的基本范围为不限性别，年龄2 岁至18 岁；另列出8项专业入选条件，需结合英文原文并由研究团队确认。
登记记录列出8项主要排除条件，具体医学含义需结合英文原文并由研究团队确认。
中国哪些地方有记录
以下地点来自登记信息，不代表此刻仍有名额；请向研究中心确认最新情况。
- Children's National Medical Center · Washington D.C.
- National Institutes of Health Clinical Center · Bethesda
- Cincinnati Children's Hospital Medical Center · Cincinnati
- Children's Hospital of Philadelphia · Philadelphia
公开的入选条件
- 1. Age Phase I: \>=3 years and \<=18 years of age at the time of study enrollment, if able to swallow whole capsules. The age limits including young children were chosen because early childhood and puberty are considered to be the greatest risk for disease pro
- Age Phase II: \>=2 and \<= 18 years. BSA \>= 0.55 m\^2, and able to swallow whole capsules.
- 2. Diagnosis: Patients with NF1 and inoperable PN, defined as PN that cannot be surgically completely removed without risk for substantial morbidity due to encasement of, or close proximity to, vital structures, invasiveness, or high vascularity of the PN. The
- Histologic confirmation of tumor is not necessary in the presence of consistent clinical and radiographic findings, but should be considered if malignant degeneration of a PN is clinically suspected.
- A PN is defined as a neurofibroma that has grown along the length of a nerve and may involve multiple fascicles and branches. A spinal PN involves two or more levels with connection between the levels or extending laterally along the nerve. In addition to PN,
- Six or more cafe-au-lait macules (\>=0.5cm in prepubertal subjects or \>=1.5 cm in post pubertal subjects)
- Freckling in axilla or groin
- Optic glioma
联系前需要确认
请继续确认中心是否启动、疾病分型、既往治疗、检查费用和知情同意安排。
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登记号：NCT01362803；登记信息更新于 2026-10-02。